Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice

Transgenic (Tg) mice expressing ∼95% of the D166V (aspartic acid to valine) mutation in the ventricular myosin regulatory light chain (RLC) shown to cause a malignant familial hypertrophic cardiomyopathy (FHC) phenotype were generated, and the skinned and intact papillary muscle fibers from the Tg-D...

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Autores principales: Kerrick, W. Glenn L., Kazmierczak, Katarzyna, Xu, Yuanyuan, Wang, Yingcai, Szczesna-Cordary, Danuta
Formato: Artigo
Lenguaje:Inglês
Publicado: The Federation of American Societies for Experimental Biology 2009
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653985/
https://ncbi.nlm.nih.gov/pubmed/18987303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-118182
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