Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo

Histone deacetylation and DNA methylation have a central role in the control of gene expression in tumours, including transcriptional repression of tumour suppressor genes and genes involved in sensitivity to chemotherapy. Treatment of cisplatin-resistant cell lines with an inhibitor of DNA methyltr...

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Bibliografiske detaljer
Main Authors: Steele, N, Finn, P, Brown, R, Plumb, J A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653770/
https://ncbi.nlm.nih.gov/pubmed/19259094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604932
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