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Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
Histone deacetylation and DNA methylation have a central role in the control of gene expression in tumours, including transcriptional repression of tumour suppressor genes and genes involved in sensitivity to chemotherapy. Treatment of cisplatin-resistant cell lines with an inhibitor of DNA methyltr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2653770/ https://ncbi.nlm.nih.gov/pubmed/19259094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604932 |
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