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Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

Neuropeptide S (NPSa), the endogenous ligand of a previously orphan receptor now named NPSR, regulates various biological functions in the brain, including arousal, locomotion, anxiety, and food intake. Here we report on a focused structure-activity study of Gly(5) which has been replaced with L and...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Guerrini, Remo, Camarda, Valeria, Trapella, Claudio, Calo’, Girolamo, Rizzi, Anna, Ruzza, Chiara, Fiorini, Stella, Marzola, Erika, Reinscheid, Rainer K., Regoli, Domenico, Salvadori, Severo
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653091/
https://ncbi.nlm.nih.gov/pubmed/19113861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8012294
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