FGF14 Regulates the Intrinsic Excitability of Cerebellar Purkinje Neurons

A missense mutation in the fibroblast growth factor 14 (FGF14) gene underlies SCA27, an autosomal dominant spinocerebellar ataxia in humans. Mice with a targeted disruption of the Fgf14 locus (Fgf14(−/−)) develop ataxia resembling human SCA27. We tested the hypothesis that loss of FGF14 affects the...

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Bibliographic Details
Main Authors: Shakkottai, Vikram G., Xiao, Maolei, Xu, Lin, Wong, Michael, Nerbonne, Jeanne M., Ornitz, David M., Yamada, Kelvin A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652849/
https://ncbi.nlm.nih.gov/pubmed/18930825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.09.019
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