Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

The processing of pro-interleukin-1β depends on activation of caspase-1. Controversy has arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of interleukin-1β (IL-1β). Here we demonstrate that human blood monocytes release processed IL-1β after a one-time stimula...

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Auteurs principaux: Netea, Mihai G., Nold-Petry, Claudia A., Nold, Marcel F., Joosten, Leo A. B., Opitz, Bastian, van der Meer, Jonathan H. M., van de Veerdonk, Frank L., Ferwerda, Gerben, Heinhuis, Bas, Devesa, Isabel, Funk, C. Joel, Mason, Robert J., Kullberg, Bart Jan, Rubartelli, Anna, van der Meer, Jos W. M., Dinarello, Charles A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2009
Sujets:
Phagocytes, Granulocytes, and Myelopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652374/
https://ncbi.nlm.nih.gov/pubmed/19104081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-146720
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