Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli

Mutations in nucleotide-binding oligomerization domain-2 (NOD2), leading to defective recognition of bacterial peptidoglycans, are associated with Crohn’s disease. The underlying mechanism that results in increased inflammation in the guts of the patients bearing NOD2 mutations is still unclear. We...

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Autores principales: Kullberg, Bart Jan, Ferwerda, Gerben, de Jong, Dirk J, Drenth, Joost P H, Joosten, Leo A B, Van der Meer, Jos W M, Netea, Mihai G
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2008
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2433311/
https://ncbi.nlm.nih.gov/pubmed/18028374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02735.x
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