Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli

Mutations in nucleotide-binding oligomerization domain-2 (NOD2), leading to defective recognition of bacterial peptidoglycans, are associated with Crohn’s disease. The underlying mechanism that results in increased inflammation in the guts of the patients bearing NOD2 mutations is still unclear. We...

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Autors principals: Kullberg, Bart Jan, Ferwerda, Gerben, de Jong, Dirk J, Drenth, Joost P H, Joosten, Leo A B, Van der Meer, Jos W M, Netea, Mihai G
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2008
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2433311/
https://ncbi.nlm.nih.gov/pubmed/18028374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02735.x
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