Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

The processing of pro-interleukin-1β depends on activation of caspase-1. Controversy has arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of interleukin-1β (IL-1β). Here we demonstrate that human blood monocytes release processed IL-1β after a one-time stimula...

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Autori principali: Netea, Mihai G., Nold-Petry, Claudia A., Nold, Marcel F., Joosten, Leo A. B., Opitz, Bastian, van der Meer, Jonathan H. M., van de Veerdonk, Frank L., Ferwerda, Gerben, Heinhuis, Bas, Devesa, Isabel, Funk, C. Joel, Mason, Robert J., Kullberg, Bart Jan, Rubartelli, Anna, van der Meer, Jos W. M., Dinarello, Charles A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Phagocytes, Granulocytes, and Myelopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652374/
https://ncbi.nlm.nih.gov/pubmed/19104081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-146720
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