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Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease
Humans with chronic granulomatous diseases (CGDs) due to mutations in p47-phox have defective NADPH activity and thus cannot generate NADPH-dependent reactive oxygen species (ROS). The role of ROS in inflammation is controversial; some in vitro studies suggest that ROS are crucial for secretion of I...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840365/ https://ncbi.nlm.nih.gov/pubmed/20133696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914795107 |
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