Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease

Humans with chronic granulomatous diseases (CGDs) due to mutations in p47-phox have defective NADPH activity and thus cannot generate NADPH-dependent reactive oxygen species (ROS). The role of ROS in inflammation is controversial; some in vitro studies suggest that ROS are crucial for secretion of I...

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Bibliografiset tiedot
Päätekijät: van de Veerdonk, Frank L., Smeekens, Sanne P., Joosten, Leo A. B., Kullberg, Bart Jan, Dinarello, Charles A., van der Meer, Jos W. M., Netea, Mihai G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2010
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840365/
https://ncbi.nlm.nih.gov/pubmed/20133696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914795107
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