KSR1 Is Required for Cell Cycle Reinitiation Following DNA Damage

KSR1 (kinase suppressor of Ras 1) is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents. We show here that KSR1 is also required for maximal ERK activation induced...

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Bibliographische Detailangaben
Hauptverfasser: Razidlo, Gina L., Johnson, Heidi J., Stoeger, Scott M., Cowan, Kenneth H., Bessho, Tadayoshi, Lewis, Robert E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652329/
https://ncbi.nlm.nih.gov/pubmed/19147494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806457200
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