Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase

Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by...

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Hlavní autoři: Baron, Rudi A., Tavaré, Richard, Figueiredo, Ana C., Błażewska, Katarzyna M., Kashemirov, Boris A., McKenna, Charles E., Ebetino, Frank H., Taylor, Adam, Rogers, Michael J., Coxon, Fraser P., Seabra, Miguel C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Enzyme Catalysis and Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652301/
https://ncbi.nlm.nih.gov/pubmed/19074143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806952200
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