Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature of the substituent in the C6 position of imidazo[1,2-a]pyridine ring was res...

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Publicado en:Front Chem
Autores principales: Kusy, Damian, Marchwicka, Aleksandra, Małolepsza, Joanna, Justyna, Katarzyna, Gendaszewska-Darmach, Edyta, Błażewska, Katarzyna Magdalena
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815931/
https://ncbi.nlm.nih.gov/pubmed/33490034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.596162
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