Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase

Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Baron, Rudi A., Tavaré, Richard, Figueiredo, Ana C., Błażewska, Katarzyna M., Kashemirov, Boris A., McKenna, Charles E., Ebetino, Frank H., Taylor, Adam, Rogers, Michael J., Coxon, Fraser P., Seabra, Miguel C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Enzyme Catalysis and Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652301/
https://ncbi.nlm.nih.gov/pubmed/19074143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806952200
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker