Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/β-Catenin Signaling

Axin, a key modulator of the Wnt/β-catenin pathway, acts as a scaffold protein in phosphorylating and degrading cytoplasmic β-catenin. Canonical Wnt proteins appear to stabilize β-catenin by inducing the interaction of LRP5/6 with Axin. This interaction requires the phosphorylation of the Ser or Thr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Ting, Li, Meng, Ding, Yu, Zhang, Le-shuai, Xi, Ying, Pan, Wei-jun, Tao, Dong-lei, Wang, Ji-yong, Li, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652294/
https://ncbi.nlm.nih.gov/pubmed/19141611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807753200
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