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Amino-termini isoforms of the Slack K(+) channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation

The rates of activation and unitary properties of Na(+)-activated K(+) (K(Na)) currents have been found to vary substantially in different types of neurones. One class of K(Na) channels is encoded by the Slack gene. We have now determined that alternative RNA splicing gives rise to at least five dif...

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Autors principals: Brown, Maile R, Kronengold, Jack, Gazula, Valeswara-Rao, Spilianakis, Charalampos G, Flavell, Richard A, von Hehn, Christian A A, Bhattacharjee, Arin, Kaczmarek, Leonard K
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652154/
https://ncbi.nlm.nih.gov/pubmed/18787033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.160861
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