Gag Mutations Strongly Contribute to HIV-1 Resistance to Protease Inhibitors in Highly Drug-Experienced Patients besides Compensating for Fitness Loss

Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) results from mutations in the viral protease (PR) that reduce PI binding but also decrease viral replicative capacity (RC). Additional mutations compensating for the RC loss subsequently accumulate within PR and in Ga...

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Detalhes bibliográficos
Main Authors: Dam, Elisabeth, Quercia, Romina, Glass, Bärbel, Descamps, Diane, Launay, Odile, Duval, Xavier, Kräusslich, Hans-Georg, Hance, Allan J., Clavel, François
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652074/
https://ncbi.nlm.nih.gov/pubmed/19300491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000345
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