Gag Mutations Strongly Contribute to HIV-1 Resistance to Protease Inhibitors in Highly Drug-Experienced Patients besides Compensating for Fitness Loss

Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) results from mutations in the viral protease (PR) that reduce PI binding but also decrease viral replicative capacity (RC). Additional mutations compensating for the RC loss subsequently accumulate within PR and in Ga...

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Hlavní autoři: Dam, Elisabeth, Quercia, Romina, Glass, Bärbel, Descamps, Diane, Launay, Odile, Duval, Xavier, Kräusslich, Hans-Georg, Hance, Allan J., Clavel, François
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652074/
https://ncbi.nlm.nih.gov/pubmed/19300491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000345
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