Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-α2β2 of E. coli Ribonucleotide Reductase

[Image: see text] The Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleotides and requires a diferric-tyrosyl radical cofactor for catalysis. RNR is composed of a 1:1 complex of two homodimeric subunits: α and β. Incubation of the E441Q...

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Detalhes bibliográficos
Main Authors: Zipse, Hendrik, Artin, Erin, Wnuk, Stanislaw, Lohman, Gregory J. S., Martino, Debora, Griffin, Robert G., Kacprzak, Sylwia, Kaupp, Martin, Hoffman, Brian, Bennati, Marina, Stubbe, JoAnne, Lees, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651750/
https://ncbi.nlm.nih.gov/pubmed/19128178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja806693s
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