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The Nucleocapsid Region of HIV-1 Gag Cooperates with the PTAP and LYPX(n)L Late Domains to Recruit the Cellular Machinery Necessary for Viral Budding
HIV-1 release is mediated through two motifs in the p6 region of Gag, PTAP and LYPX(n)L, which recruit cellular proteins Tsg101 and Alix, respectively. The Nucleocapsid region of Gag (NC), which binds the Bro1 domain of Alix, also plays an important role in HIV-1 release, but the underlying mechanis...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651531/ https://ncbi.nlm.nih.gov/pubmed/19282983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000339 |
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