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Ligand-induced global transitions in the catalytic domain of protein kinase A
Conformational transitions play a central role in the phosphorylation mechanisms of protein kinase. To understand the nature of these transitions, we investigated the dynamics of nucleotide binding to the catalytic domain of PKA, a prototype for the protein kinase enzyme family. The open-to-closed t...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651249/ https://ncbi.nlm.nih.gov/pubmed/19204278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813266106 |
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