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A Novel Disulfide Bond in the SH2 Domain of the C-Terminal Src Kinase Controls Catalytic Activity

The SH2 domain of the C-terminal Src kinase [Csk] contains a unique disulfide bond not present in other known SH2 domains. To investigate whether this unusual disulfide bond could serve a novel function, the effects of disulfide bond formation on catalytic activity of the full-length protein and on...

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Bibliographic Details
Main Authors: Mills, Jamie, Whitford, Paul, Shaffer, Jennifer, Onuchic, Jose, Adams, Joseph A., Jennings, Patricia A.
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741090/
https://ncbi.nlm.nih.gov/pubmed/17137590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.10.076
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