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Internal strain regulates the nucleotide binding site of the kinesin leading head

In the presence of ATP, kinesin proceeds along the protofilament of microtubule by alternated binding of two motor domains on the tubulin binding sites. Because the processivity of kinesin is much higher than other motor proteins, it has been speculated that there exists a mechanism for allosteric r...

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Autori principali: Hyeon, Changbong, Onuchic, José N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892953/
https://ncbi.nlm.nih.gov/pubmed/17287347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610939104
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