The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

DNA double strand breaks (DSBs) initiate reversible cellular checkpoint and repair activities. Whereas many of the activating events at DSBs have recently been elucidated, the mechanisms used to terminate responses at these sites are largely undefined. Here we report a pathway required to reverse RN...

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Main Authors: Shao, Genze, Lilli, Dana R., Patterson-Fortin, Jeffrey, Coleman, Kara A., Morrissey, Devon E., Greenberg, Roger A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651241/
https://ncbi.nlm.nih.gov/pubmed/19202061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807485106
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