Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis

Enhanced angiogenesis is a hallmark of cancer. Pleiotrophin (PTN) is an angiogenic factor that is produced by many different human cancers and stimulates tumor blood vessel formation when it is expressed in malignant cancer cells. Recent studies show that monocytes may give rise to vascular endothel...

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Main Authors: Chen, Haiming, Campbell, Richard A., Chang, Yunchao, Li, Mingjie, Wang, Cathy S., Li, Jennifer, Sanchez, Eric, Share, Michael, Steinberg, Jeffrey, Berenson, Ariana, Shalitin, Dror, Zeng, Zhaohui, Gui, Dorina, Perez-Pinera, Pablo, Berenson, Ronald J., Said, Jonathan, Bonavida, Benjamin, Deuel, Thomas F., Berenson, James R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651013/
https://ncbi.nlm.nih.gov/pubmed/19060246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-133751
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