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Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment

Pleiotrophin (PTN, Ptn) is an 18-kDa secretory cytokine expressed in many breast cancers; however, the significance of Ptn expression in breast cancer has not been established. We have now tested three models to determine the role of inappropriate expression of Ptn in breast cancer. Mouse mammary tu...

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Autors principals: Chang, Yunchao, Zuka, Masahiko, Perez-Pinera, Pablo, Astudillo, Aurora, Mortimer, Joanne, Berenson, James R., Deuel, Thomas F.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904160/
https://ncbi.nlm.nih.gov/pubmed/17578909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704366104
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