β-Arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis

The activation of endothelin-A receptor (ET(A)R) by endothelin-1 (ET-1) has a critical role in ovarian tumorigenesis and progression. To define the molecular mechanism in ET-1-induced tumor invasion and metastasis, we focused on β-arrestins as scaffold and signaling proteins of G protein-coupled rec...

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Detalhes bibliográficos
Main Authors: Rosanò, Laura, Cianfrocca, Roberta, Masi, Stefano, Spinella, Francesca, Di Castro, Valeriana, Biroccio, Annamaria, Salvati, Erica, Nicotra, Maria Rita, Natali, Pier Giorgio, Bagnato, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650347/
https://ncbi.nlm.nih.gov/pubmed/19202075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807158106
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