Endothelin Receptor Blockade Inhibits Molecular Effectors of Kaposi’s Sarcoma Cell Invasion and Tumor Growth in Vivo

Endothelin-1 (ET-1) and its receptors are overexpressed in human Kaposi’s sarcoma lesions. Here we show that in human KS IMM cell line ET-1 increased secretion and activation of matrix-metalloproteinase-2 (MMP-2), -3, -7, -9 and -13, as well as of membrane-type 1-MMP (MT1-MMP). ET-1 and ET-3 also en...

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Detalhes bibliográficos
Main Authors: Rosanò, Laura, Spinella, Francesca, Di Castro, Valeriana, Nicotra, Maria Rita, Albini, Adriana, Natali, Pier Giorgio, Bagnato, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868202/
https://ncbi.nlm.nih.gov/pubmed/12875994
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