Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1α in Melanoma Cells

BACKGROUND: The endothelin B receptor (ET(B)R) promotes tumorigenesis and melanoma progression through activation by endothelin (ET)-1, thus representing a promising therapeutic target. The stability of hypoxia-inducible factor (HIF)-1α is essential for melanomagenesis and progression, and is contro...

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Main Authors: Spinella, Francesca, Rosanò, Laura, Del Duca, Martina, Di Castro, Valeriana, Nicotra, Maria Rita, Natali, Pier Giorgio, Bagnato, Anna
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888584/
https://ncbi.nlm.nih.gov/pubmed/20574527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011241
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