Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

The development of a vaccine for tuberculosis requires a combination of antigens and adjuvants capable of inducing appropriate and long-lasting T cell immunity. We evaluated Mtb72F formulated in AS02A in the cynomolgus monkey model. The vaccine was immunogenic and caused no adverse reactions. When m...

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Main Authors: Reed, Steven G., Coler, Rhea N., Dalemans, Wilfried, Tan, Esterlina V., DeLa Cruz, Eduardo C., Basaraba, Randall J., Orme, Ian M., Skeiky, Yasir A. W., Alderson, Mark R., Cowgill, Karen D., Prieels, Jean-Paul, Abalos, Rodolfo M., Dubois, Marie-Claude, Cohen, Joe, Mettens, Pascal, Lobet, Yves
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650151/
https://ncbi.nlm.nih.gov/pubmed/19188599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712077106
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