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Smad3-Deficient Chondrocytes Have Enhanced BMP Signaling and Accelerated Differentiation
Smad3 deficiency accelerates chondrocyte maturation and leads to osteoarthritis. Primary chondrocytes without Smad3 lack compensatory increases of TGF-β signaling factors, but BMP-related gene expression is increased. Smad2 or Smad3 overexpression and BMP blockade abrogate accelerated maturation in...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2005
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2649698/ https://ncbi.nlm.nih.gov/pubmed/16355269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.050911 |
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