Smad3-Deficient Chondrocytes Have Enhanced BMP Signaling and Accelerated Differentiation

Smad3 deficiency accelerates chondrocyte maturation and leads to osteoarthritis. Primary chondrocytes without Smad3 lack compensatory increases of TGF-β signaling factors, but BMP-related gene expression is increased. Smad2 or Smad3 overexpression and BMP blockade abrogate accelerated maturation in...

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Bibliografiske detaljer
Main Authors: Li, Tian-Fang, Darowish, Michael, Zuscik, Michael J, Chen, Di, Schwarz, Edward M, Rosier, Randy N, Drissi, Hicham, O’Keefe, Regis J
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649698/
https://ncbi.nlm.nih.gov/pubmed/16355269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.050911
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