Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2

Chondrocytes express RANKL, but their role in osteoclastogenesis is not clear. We report that hypertrophic chondrocytes induce osteoclast formation through RANKL production stimulated by BMP2 and Runx2/Smad1 and thus they may regulate resorption of calcified matrix by osteoclasts at growth plates. I...

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Detalhes bibliográficos
Main Authors: Usui, Michihiko, Xing, Lianping, Drissi, Hicham, Zuscik, Michael, O'Keefe, Regis, Chen, Di, Boyce, Brendan F
Formato: Artigo
Idioma:Inglês
Publicado em: Amer Soc Bone & Mineral Res. 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636701/
https://ncbi.nlm.nih.gov/pubmed/17967138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.071025
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