Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2

Chondrocytes express RANKL, but their role in osteoclastogenesis is not clear. We report that hypertrophic chondrocytes induce osteoclast formation through RANKL production stimulated by BMP2 and Runx2/Smad1 and thus they may regulate resorption of calcified matrix by osteoclasts at growth plates. I...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Usui, Michihiko, Xing, Lianping, Drissi, Hicham, Zuscik, Michael, O'Keefe, Regis, Chen, Di, Boyce, Brendan F
Format: Artigo
Jezik:Inglês
Izdano: Amer Soc Bone & Mineral Res. 2008
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636701/
https://ncbi.nlm.nih.gov/pubmed/17967138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.071025
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items