Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2

Chondrocytes express RANKL, but their role in osteoclastogenesis is not clear. We report that hypertrophic chondrocytes induce osteoclast formation through RANKL production stimulated by BMP2 and Runx2/Smad1 and thus they may regulate resorption of calcified matrix by osteoclasts at growth plates. I...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Usui, Michihiko, Xing, Lianping, Drissi, Hicham, Zuscik, Michael, O'Keefe, Regis, Chen, Di, Boyce, Brendan F
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Amer Soc Bone & Mineral Res. 2008
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636701/
https://ncbi.nlm.nih.gov/pubmed/17967138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.071025
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