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Solution NMR Structure of the C-terminal EF-hand Domain of Human Cardiac Sodium Channel Na(V)1.5
The voltage-gated sodium channel Na(V)1.5 is responsible for the initial upstroke of the action potential in cardiac tissue. Levels of intracellular calcium modulate inactivation gating of Na(V)1.5, in part through a C-terminal EF-hand calcium binding domain. The significance of this structure is un...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2649110/ https://ncbi.nlm.nih.gov/pubmed/19074138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807747200 |
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