Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

The formation of cysteine-sulfinic acid has recently become appreciated as a modification that links protein function to cellular oxidative status. Human DJ-1, a protein associated with inherited parkinsonism, readily forms cysteine-sulfinic acid at a conserved cysteine residue (Cys(106) in human DJ...

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Bibliographic Details
Main Authors: Blackinton, Jeff, Lakshminarasimhan, Mahadevan, Thomas, Kelly J., Ahmad, Rili, Greggio, Elisa, Raza, Ashraf S., Cookson, Mark R., Wilson, Mark A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649108/
https://ncbi.nlm.nih.gov/pubmed/19124468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806599200
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