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Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1
A number of missense mutations in the oxidative stress response protein DJ-1 are implicated in rare forms of familial Parkinsonism. The best-characterized Parkinsonian DJ-1 missense mutation, L166P, disrupts homodimerization and results in a poorly folded protein. The molecular basis by which the ot...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657723/ https://ncbi.nlm.nih.gov/pubmed/18181649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701189c |
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