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Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1
A number of missense mutations in the oxidative stress response protein DJ-1 are implicated in rare forms of familial Parkinsonism. The best-characterized Parkinsonian DJ-1 missense mutation, L166P, disrupts homodimerization and results in a poorly folded protein. The molecular basis by which the ot...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657723/ https://ncbi.nlm.nih.gov/pubmed/18181649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701189c |
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