The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the suggestion that DJ-1 is protective under these conditions. We addressed whether this represents a posttranslationa...

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Main Authors: Canet-Avilés, Rosa M., Wilson, Mark A., Miller, David W., Ahmad, Rili, McLendon, Chris, Bandyopadhyay, Sourav, Baptista, Melisa J., Ringe, Dagmar, Petsko, Gregory A., Cookson, Mark R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC428480/
https://ncbi.nlm.nih.gov/pubmed/15181200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402959101
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