The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the suggestion that DJ-1 is protective under these conditions. We addressed whether this represents a posttranslational mod...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Canet-Avilés, Rosa M., Wilson, Mark A., Miller, David W., Ahmad, Rili, McLendon, Chris, Bandyopadhyay, Sourav, Baptista, Melisa J., Ringe, Dagmar, Petsko, Gregory A., Cookson, Mark R.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2004
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC428480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15181200/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402959101
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