Putative Re-entrant Loop 1 of AE2 Transmembrane Domain Has a Major Role in Acute Regulation of Anion Exchange by pH

Normal pH sensitivity of the SLC4A2/AE2 anion exchanger requires transmembrane domain (TMD) amino acid (aa) residues not conserved in the homologous but relatively pH-insensitive SLC4A1/AE1 polypeptide. We tested the hypothesis that the nonconserved aa cluster (1075)DKPK(1078) within the first putat...

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Bibliographic Details
Main Authors: Stewart, Andrew K., Kurschat, Christine E., Vaughan-Jones, Richard D., Alper, Seth L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649077/
https://ncbi.nlm.nih.gov/pubmed/19103596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802051200
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