RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells

BACKGROUND: With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulation of c-MYC is evident in numerous human cancers. In MB, over-expression of c-M...

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Hlavní autoři: von Bueren, André O, Shalaby, Tarek, Oehler-Jänne, Christoph, Arnold, Lucia, Stearns, Duncan, Eberhart, Charles G, Arcaro, Alexandre, Pruschy, Martin, Grotzer, Michael A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648994/
https://ncbi.nlm.nih.gov/pubmed/19134217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-10
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