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Genome-Scale Reconstruction of Escherichia coli's Transcriptional and Translational Machinery: A Knowledge Base, Its Mathematical Formulation, and Its Functional Characterization

Metabolic network reconstructions represent valuable scaffolds for ‘-omics’ data integration and are used to computationally interrogate network properties. However, they do not explicitly account for the synthesis of macromolecules (i.e., proteins and RNA). Here, we present the first genome-scale,...

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Main Authors: Thiele, Ines, Jamshidi, Neema, Fleming, Ronan M. T., Palsson, Bernhard Ø.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648898/
https://ncbi.nlm.nih.gov/pubmed/19282977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000312
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