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Genome-Scale Reconstruction of Escherichia coli's Transcriptional and Translational Machinery: A Knowledge Base, Its Mathematical Formulation, and Its Functional Characterization

Metabolic network reconstructions represent valuable scaffolds for ‘-omics’ data integration and are used to computationally interrogate network properties. However, they do not explicitly account for the synthesis of macromolecules (i.e., proteins and RNA). Here, we present the first genome-scale,...

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Detalhes bibliográficos
Main Authors: Thiele, Ines, Jamshidi, Neema, Fleming, Ronan M. T., Palsson, Bernhard Ø.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648898/
https://ncbi.nlm.nih.gov/pubmed/19282977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000312
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