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A structural interpretation of the effect of GC-content on efficiency of RNA interference
BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) has become a powerful technique for eukaryotic gene knockdown. siRNA GC-content negatively correlates with RNAi efficiency, and it is of interest to have a convincing mechanistic interpreta...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648742/ https://ncbi.nlm.nih.gov/pubmed/19208134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S1-S33 |
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