Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

Mutations in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually linked to autosomal recessive early-onset familial forms of Parkinson disease (PD). Although mutations in these genes lead to the same disease state, the functional relationships between them and how their respect...

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Detalhes bibliográficos
Main Authors: Xiong, Hui, Wang, Danling, Chen, Linan, Choo, Yeun Su, Ma, Hong, Tang, Chengyuan, Xia, Kun, Jiang, Wei, Ronai, Ze’ev, Zhuang, Xiaoxi, Zhang, Zhuohua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648688/
https://ncbi.nlm.nih.gov/pubmed/19229105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37617
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