Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcγRIIa and the integrin β3 cytoplasmic domain

Thrombocytopenia and thrombosis following treatment with the integrin αIIbβ3 antagonist eptifibatide are rare complications caused by patient antibodies specific for ligand-occupied αIIbβ3. Whether such antibodies induce platelet clearance by simple opsonization, by inducing mild platelet activation...

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Bibliografske podrobnosti
Main Authors: Gao, Cunji, Boylan, Brian, Bougie, Dan, Gill, Joan C., Birenbaum, Jessica, Newman, Debra K., Aster, Richard H., Newman, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648674/
https://ncbi.nlm.nih.gov/pubmed/19197137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36745
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