INTERACTIONS BETWEEN HSP70 AND THE HYDROPHOBIC CORE OF ALPHA–SYNUCLEIN INHIBIT FIBRIL ASSEMBLY

Molecular chaperones of the heat shock protein 70 (Hsp70) family counteract protein misfolding in a variety of neurodegenerative disease models. To determine whether human Hsp70 exerts similar effects on the aggregation of alpha-synuclein (α-Syn), the key component of insoluble fibrils present in Pa...

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Bibliographic Details
Main Authors: Luk, Kelvin C., Mills, Ian P., Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648307/
https://ncbi.nlm.nih.gov/pubmed/18975920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801475r
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