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p53, Cyclin-dependent Kinase and Abnormal Amplification of Centrosomes
Centrosomes play a critical role in formation of bipolar mitotic spindles, an essential event for accurate chromosome segregation into daughter cells. Numeral abnormalities of centrosomes (centrosome amplification) occur frequently in cancers, and are considered to be the major cause of chromosome i...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2647860/ https://ncbi.nlm.nih.gov/pubmed/18472015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2008.04.002 |
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