Characterization of Quinolinate Synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii Indicates that [4Fe-4S] Clusters Are Common Cofactors Throughout this Class of Enzymes

Quinolinate synthase (NadA) catalyzes a unique condensation reaction between iminoaspartate and dihydroxyacetone phosphate, affording quinolinic acid, a central intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD). Iminoaspartate is generated via the action of l-aspartate oxid...

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Autors principals: Saunders, Allison H., Griffiths, Amy E., Lee, Kyung-Hoon, Cicchillo, Robert M., Tu, Loretta, Stromberg, Jeffrey A., Krebs, Carsten, Booker, Squire J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647848/
https://ncbi.nlm.nih.gov/pubmed/18803397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801268f
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