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CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4–deficient mice develop fatal, early onset lymphoproliferative disease. However, chimer...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646578/ https://ncbi.nlm.nih.gov/pubmed/19188497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081811 |
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