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CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4–deficient mice develop fatal, early onset lymphoproliferative disease. However, chimer...

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Detalhes bibliográficos
Main Authors: Friedline, Randall H., Brown, David S., Nguyen, Hai, Kornfeld, Hardy, Lee, JinHee, Zhang, Yi, Appleby, Mark, Der, Sandy D., Kang, Joonsoo, Chambers, Cynthia A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646578/
https://ncbi.nlm.nih.gov/pubmed/19188497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081811
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